Abstract: Background/objective: The role of foetal haemoglobin (HbF) on the modulation of clinical manifestations in sickle cell disease is well known but there is inconsistency as to the levels of HbF that may protective against the development of liver disease. This study evaluates the impact of HbF on biochemical markers of liver function in sickle cell disease (SCD) patients in steady clinical state. Materials and Methods: Liver function tests: aspartate amino transferase, alanine amino transferase, alkaline phosphatase, bilirubin and proteins as well as HbF were assayed in SCD patients using colorimetric methods. Results: Out of 100 SCD patients, 24 % had high (>5%) HbF while 76 % had low (<4.9%) HbF levels. Those subjects with h...
Background: Liver damage is a severe and frequent complication in Sickle Cell Disease (SCD), mainly ...
Background: Sickle cell disease (SCD) is the most common inherited monogenic genetic disorder in Ind...
Sickle cell disease (SCD) and β thalassaemia (β thal) are congenital blood disorders caused by abnor...
Background: Fetal hemoglobin (HbF) can inhibit the deoxygenation induced polymerization of sickle he...
Background/Aim: There are conflicting reports on the potential protective effects of foetal haemoglo...
Background and Objective: Multiorgan failure including liver dysfunction is a common finding in sick...
Background / Objective: The presence of persistent high fetal hemoglobin (HbF) in sickle cells disea...
Objective: This study aimed to evaluate the influence of fetal hemoglobin (Hb F) on hemolysis biomark...
Background: Sickle cell disease (SCD) is frequently associated with liver disease. The constant stat...
Summary High foetal haemoglobin (HbF) levels are believed to ameliorate the manifestations of homozy...
Background: Foetal haemoglobin (HbF) is a major modifying factor influencing sickle cell disease (SC...
Background: Foetal haemoglobin has been implicated in the modulation of sickle cell crisis. Its leve...
Summary: Hepatic dysfunction occurs commonly in children with sickle cell disease (SCD). Although th...
Using the sensitive ELISA technique, 213 patients with sickle cell anemia (112 males and 101 females...
Summary We investigated the prevalence of positive viral hepatitis titres in sickle cell disease (SC...
Background: Liver damage is a severe and frequent complication in Sickle Cell Disease (SCD), mainly ...
Background: Sickle cell disease (SCD) is the most common inherited monogenic genetic disorder in Ind...
Sickle cell disease (SCD) and β thalassaemia (β thal) are congenital blood disorders caused by abnor...
Background: Fetal hemoglobin (HbF) can inhibit the deoxygenation induced polymerization of sickle he...
Background/Aim: There are conflicting reports on the potential protective effects of foetal haemoglo...
Background and Objective: Multiorgan failure including liver dysfunction is a common finding in sick...
Background / Objective: The presence of persistent high fetal hemoglobin (HbF) in sickle cells disea...
Objective: This study aimed to evaluate the influence of fetal hemoglobin (Hb F) on hemolysis biomark...
Background: Sickle cell disease (SCD) is frequently associated with liver disease. The constant stat...
Summary High foetal haemoglobin (HbF) levels are believed to ameliorate the manifestations of homozy...
Background: Foetal haemoglobin (HbF) is a major modifying factor influencing sickle cell disease (SC...
Background: Foetal haemoglobin has been implicated in the modulation of sickle cell crisis. Its leve...
Summary: Hepatic dysfunction occurs commonly in children with sickle cell disease (SCD). Although th...
Using the sensitive ELISA technique, 213 patients with sickle cell anemia (112 males and 101 females...
Summary We investigated the prevalence of positive viral hepatitis titres in sickle cell disease (SC...
Background: Liver damage is a severe and frequent complication in Sickle Cell Disease (SCD), mainly ...
Background: Sickle cell disease (SCD) is the most common inherited monogenic genetic disorder in Ind...
Sickle cell disease (SCD) and β thalassaemia (β thal) are congenital blood disorders caused by abnor...