Alterations in Postprandial Hepatic Glycogen Metabolism in Type

Decreased skeletal muscle glucose disposal and in-creased endogenous glucose production (EGP) contrib-ute to postprandial hyperglycemia in type 2 diabetes, but the contribution of hepatic glycogen metabolism remains uncertain. Hepatic glycogen metabolism and EGP were monitored in type 2 diabetic patients and nondiabetic volunteer control subjects (CON) after mixed meal ingestion and during hyperglycemic-hyper-insulinemic-somatostatin clamps applying 13C nuclear magnetic resonance spectroscopy (NMRS) and variable infusion dual-tracer technique. Hepatocellular lipid (HCL) content was quantified by 1H NMRS. Before dinner, hepatic glycogen was lower in type 2 diabetic patients (227 6 vs. CON: 275 10 mmol/l liver, P < 0.001). After meal ingestion, net synthetic rates wer