Article The Role of the Major Histocompatibility Complex Region in Cognition and Brain Structure: A Schizophrenia GWAS Follow-Up

Objective: The authors investigated the effects of recently identified genome-wide significant schizophrenia genetic risk var-iants on cognition and brain structure. Method: A panel of six single-nucleotide polymorphisms (SNPs) was selected to represent genome-wide significant loci from three recent genome-wide associa-tion studies (GWAS) for schizophrenia and was tested for association with cognitive measures in 346 patients with schizophre-nia and 2,342 healthy comparison sub-jects. Nominally significant results were evaluated for replication in an indepen-dent case-control sample. For SNPs show