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a r t i c l e i n f o extensively investigated owning to their tunable physical and chemical properties, lowbatch-to-batch variation, ease of fabrication andmodification, and low risk of disease transmission [6e10]. In the attributed to their high mechanical strength, and in vivo bio-compatibility. Despite the interesting physical and chemical prop-erties, some of these polyesters create an acidic local environment upon degradation that causes inflammation to the surrounding tis-sues [10,13]. Moreover, the conventional polyesters follow the bulk degradation mechanism and display exponential decay in their mechanical properties with degradation [14]. Poly(glycerol sebacate) (PGS), a tough elastomer, has been proposed for tissue engineering applications due to controlled an