International Journal of Cancer Therapy and Oncology www.ijcto.org

Human pluripotent stem cells have the theoretic ability to differentiate into all the somatic cell types in the human body, whereas human somatic stem/progenitor/precursor cells (hSSCs) are multipotent, indicating that their potential is restricted to a particular germ layer, organ, or tissue of origin.1-3 Pluripotent human embryonic stem cells (hESCs), derived from the inner cell mass or epiblast of the human blastocyst, have both the unconstrained capacity for long-term stable undifferentiated growth in culture and the intrinsic potential for differentiation into all the somatic cell types in the human body, holding tremendous potential for restoring human tissue and organ function.1-3 These proper-ties offer pluripotent hESCs as an unlimited source to gener-ate the diversity of human somatic cell types for regenerative medicine and as a model system for studying mechanism