The Drosophila Amidase PGRP-LB Modulates the Im Response to Bacterial Infec

mDrosophila is devoid of an adaptive immune system and relies solely on innate immune reactions for its defense (Kaneko et al., 2005; Royet et al., 2005). One of the key features of the Drosophila immune response is the syn-thesis of several antimicrobial peptides (AMPs) with dis-(Kaneko et al., 2004; Mellroth et al., 2005; Stenbak et al., 2004). Finally, PGRP-LE, a secreted PGRP that binds preferentially to DAP-type PGN, functions syner-gistically with PGRP-LC in Imd pathway activation (Takehana et al., 2004). In contrast, another subgroup of PGRPs referred to as catalytic PGRPs have demon