Necrotizing Soft-Tissue Infection of a Limb: Clinical Presentation and Factors Related to Mortality

Background: Necrotizing fasciitis is a rare and often fatal soft-tissue infection. Prompt diagnosis and immediate aggressive surgical debridement of all compromised tissues are critical to reducing morbidity and mortality in these rapidly progressive infections. The purpose of this study was to analyze the clin-ical presentation and evaluate factors that determine mortality associated with this uncommon surgical emergency. Methods: The study retrospectively investigated the medical records of 22 patients who were diagnosed and treated for necrotizing fasciitis of the lower extremity, 14 of whom had involvement of the foot (nine patients) or foot and ankle (five patients) at our hospital. The data collected for each of the 22 patients were age, sex, underlying systemic factors, location of infec-tion, duration of symptoms, portal of entry of infection, initia