Mechanisms of remodeling of gap junction distributions and the development of anatomic substrates of arrhythmias

that result from these myocardial responses to injury can Alteration of structure (remodeling) is a fundamental also change patterns of electrical activation of the heart response of the heart to injury or disease. It originates in that may enhance the risk of developing a serious ventricu-changes in gene expression which, in turn, alter the types lar arrhythmia. For example, sudden death in patients wh