Add to ORKGIn leprosy, type 1 reaction (T1R) and type 2 reaction (T2R) are major causes of nerve injury and permanent disabilities. A previous study on plasma levels of 27 cytokines in patients with T1R or T2R and controls with nonreactional leprosy identified the gene for interleukin 6 (IL-6) as a candidate for genetic analysis. Two nested case-control studies were built from a cohort of 409 patients with leprosy from central Brazil, monitored for T1R and T2R. There was evidence for association between T2R and IL-6 tag single-nucleotide polymorphisms rs2069832 (P5.002), rs2069840 (P5.03), and rs2069845 (P5.04), with information on the entire IL-6 locus, as well as functional IL-6 variant rs1800795 (P 5.005). Moreover, IL-6 plasma levels in patients w...
Leprosy is a chronic infectious disease caused by an obligate intracellular bacterium known as Mycob...
Abstract Background The major factors contributing for nerve damage and permanent disabilities in le...
Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is the leading cause of non-t...
In leprosy, type 1 reaction (T1R) and type 2 reaction (T2R) are major causes of nerve injury and per...
Type-1 (T1R) and Type-2 (T2R) leprosy reactions (LR), which affect up to 50% of leprosy patients, ar...
The pathways that trigger exacerbated immune reactions in leprosy could be determined by genetic var...
SummaryObjectiveTo determine whether cytokine polymorphisms are associated with leprosy and/or their...
BACKGROUND Leprosy or hansen’s disease is a spectral disease whose clinical forms mostly depends on...
BACKGROUND Leprosy or hansen’s disease is a spectral disease whose clinical forms mostly depends on...
The ancient disease of leprosy can cause severe disability and disfigurement and is still a major he...
Patterns of production of specific cytokines are accepted as standards for T-lymphocyte subsets in d...
Previous analyses indicate major gene control of susceptibility to leprosy per se and the HLA class ...
Background: The ILEP Nerve Function Impairment in Reaction (INFIR) is a cohort study designed to ide...
Background: The ILEP Nerve Function Impairment in Reaction (INFIR) is a cohort study designed to ide...
Abstract Background The clinical management of leprosy Type 1 (T1R) and Type 2 (T2R) reactions pose ...
Leprosy is a chronic infectious disease caused by an obligate intracellular bacterium known as Mycob...
Abstract Background The major factors contributing for nerve damage and permanent disabilities in le...
Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is the leading cause of non-t...
In leprosy, type 1 reaction (T1R) and type 2 reaction (T2R) are major causes of nerve injury and per...
Type-1 (T1R) and Type-2 (T2R) leprosy reactions (LR), which affect up to 50% of leprosy patients, ar...
The pathways that trigger exacerbated immune reactions in leprosy could be determined by genetic var...
SummaryObjectiveTo determine whether cytokine polymorphisms are associated with leprosy and/or their...
BACKGROUND Leprosy or hansen’s disease is a spectral disease whose clinical forms mostly depends on...
BACKGROUND Leprosy or hansen’s disease is a spectral disease whose clinical forms mostly depends on...
The ancient disease of leprosy can cause severe disability and disfigurement and is still a major he...
Patterns of production of specific cytokines are accepted as standards for T-lymphocyte subsets in d...
Previous analyses indicate major gene control of susceptibility to leprosy per se and the HLA class ...
Background: The ILEP Nerve Function Impairment in Reaction (INFIR) is a cohort study designed to ide...
Background: The ILEP Nerve Function Impairment in Reaction (INFIR) is a cohort study designed to ide...
Abstract Background The clinical management of leprosy Type 1 (T1R) and Type 2 (T2R) reactions pose ...
Leprosy is a chronic infectious disease caused by an obligate intracellular bacterium known as Mycob...
Abstract Background The major factors contributing for nerve damage and permanent disabilities in le...
Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is the leading cause of non-t...