Dendritic Poly-[N-(2- Hydroxyethyl)-L-Glutamine] as Potential Drug Carrier

ABSTRACT: Dendritic poly-[N-(2-hydroxyethyl)-L-glutamine] (PHEG) with different molecular weights were synthesized by aminolysis of dendritic poly-(γ-benzyl-L-glutamate) (PBG), which was obtained by polymerization of the corresponding N-carboxyanhydride (NCA) with poly(amido amine) (PAMAM, starburst®) of the fourth generation as initiator. Dynamic light scattering (DLS) was used to determine the size of the polymeric carriers and to compare the dendritic polymer to the linear analogue. The body distribution and blood clearance of 125I-radiolabelled linear and dendritic PHEG with similar molecu-lar weight were investigated in female BALB/c mice. KEY WORDS: polymeric carrier, poly-[N-(2-hydroxyethyl)-L-glutamine], body distribution, dendrimers, poly(amino amide