© 2006 Atlas of Genetics and Cytogenetics in Oncology and Haematology Identity

Local order: Genes flanking ALOX15 in centromere to telomere direction on 17p13 are:- MYBBP1A 17p13.3 MYB binding protein (P160) 1a,- GGT6 17p13.2 homolog of gamma-glutamyltransferase 6,- LOC124974 17p13.2, thioredoxin 1 pseudogene 4,- SMTNL2 17p13.2 smoothelin-like 2,- ALOX15 17p13.2 arachidonate 15-lipoxygenase (Homo sapiens),- PELP1 17p13.2 proline, glutamic acid and leucine rich protein 1,- ARRB2 17p13 arrestin, beta 2. Note: Arachidonate 15-Lipoxygenase (15-LOX-1) is one of several LOX isoforms that oxygenates polyunsaturated fatty acids as well as complex substrates such as biomembranes. Its expression is associated with the development of inflammatory diseases such as atherosclerosis, asthma, cancer and osteoporosis. DNA/RNA Note: With the exception of ALOX5, all human LOX genes, including ALOX15, are clustered on the short arm of chromosome 17 within a few megabases of each other. ALOX12, which has 86 % sequence homology to ALOX15 is in closest proximity (17p13.1). Since chromosome 17 is known for gene duplications, the multiple LOX genes on the same chromosome may be as a result of such duplications