Add to ORKG(See the editorial commentary by Taylor and Juliano on pages 335–7.) Background. Artemisinin-based combination therapies, including artemether-lumefantrine (AL) and dihy-droartemisinin-piperaquine (DP), are recommended to treat uncomplicated falciparum malaria. Sensitivities to components of AL and DP are impacted by polymorphisms in pfmdr1 and pfcrt. We monitored changes in preva-lences of polymorphisms in Tororo, Uganda, from 2008 to 2012. Methods. Polymorphic loci in pfmdr1 and pfcrt were characterized in samples from 312 children randomized to AL or DP for each episode of uncomplicated malaria (50 samples per arm for each 3-month interval) utilizing a fluorescent microsphere assay. Treatment outcomes and impacts of prior therapies were ...
Plasmodium falciparum uncomplicated malaria can successfully be treated with an artemisinin-based co...
Background The emergence of resistance against artemisinin combination treatment is a major concern ...
Background The emergence of resistance against artemisinin combination treatment is a major concern ...
BACKGROUND: Altered sensitivity to multiple antimalarial drugs is mediated by polymorphisms in pfmdr...
BACKGROUND: Altered sensitivity to multiple antimalarial drugs is mediated by polymorphisms in pfmdr...
We compared the prevalence of key pfmdr1 alleles between pretreatment Plasmodium falciparum parasite...
Plasmodium falciparum uncomplicated malaria can successfully be treated with an artemisinin-based co...
The emergence of resistance against artemisinin combination treatment is a major concern for malaria...
Artemether-lumefantrine (AL) and artesunate-amodiaquine (AS-AQ) are the most commonly used artemisin...
Artemether-lumefantrine (AL) and artesunate-amodiaquine (AS-AQ) are the most commonly used artemisin...
Artemisinin-based combination therapies (ACTs) are the main option to treat malaria, and their effic...
International audienceArtemisinin-based combination therapies (ACTs) are the main option to treat ma...
International audienceArtemisinin-based combination therapies (ACTs) are the main option to treat ma...
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisi...
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisi...
Plasmodium falciparum uncomplicated malaria can successfully be treated with an artemisinin-based co...
Background The emergence of resistance against artemisinin combination treatment is a major concern ...
Background The emergence of resistance against artemisinin combination treatment is a major concern ...
BACKGROUND: Altered sensitivity to multiple antimalarial drugs is mediated by polymorphisms in pfmdr...
BACKGROUND: Altered sensitivity to multiple antimalarial drugs is mediated by polymorphisms in pfmdr...
We compared the prevalence of key pfmdr1 alleles between pretreatment Plasmodium falciparum parasite...
Plasmodium falciparum uncomplicated malaria can successfully be treated with an artemisinin-based co...
The emergence of resistance against artemisinin combination treatment is a major concern for malaria...
Artemether-lumefantrine (AL) and artesunate-amodiaquine (AS-AQ) are the most commonly used artemisin...
Artemether-lumefantrine (AL) and artesunate-amodiaquine (AS-AQ) are the most commonly used artemisin...
Artemisinin-based combination therapies (ACTs) are the main option to treat malaria, and their effic...
International audienceArtemisinin-based combination therapies (ACTs) are the main option to treat ma...
International audienceArtemisinin-based combination therapies (ACTs) are the main option to treat ma...
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisi...
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisi...
Plasmodium falciparum uncomplicated malaria can successfully be treated with an artemisinin-based co...
Background The emergence of resistance against artemisinin combination treatment is a major concern ...
Background The emergence of resistance against artemisinin combination treatment is a major concern ...