Central injection of physostigmine attenuates exercise-induced pressor response in conscious cats

Central injection of physostigmine attenuates exercise-induced pressor response in conscious cats. Am. J. PhysioZ. 273 (Regulatory Integrative Comp. Physiol. 42): R393-R399, 1997.-The effects of intracerebroventricular administration of physostigmine, a cholinesterase inhibitor, on the cardiovas-cular responses evoked by static voluntary exercise were investigated using conscious cats. Four cats were trained to press a bar (200-650 g) with one forelimb for at least 20 s. The changes in mean arterial pressure (MAP), heart rate (HR), and developed force during the first five trials in 30 min by each individual cat were averaged, and a mean of the four values was then calculated. After the cats exercised for 30 min, either artificial cerebrospinal fluid (CSF) or physostig-mine (5 pg) was administered intracerebroventricularly. Be-fore physostigmine, exercise trials by the cats increased MA