To determine the carcinogenic potential of sodium fluoride (NaF), we fed Sprague-Dawley rats a diet containing NaF for up to 99 weeks. Rats receiving NaF at a dose of 4,10, or 25 mg/kg per day added to a low-fluoride diet were compared with controls receiving either a low-fluoride diet or labora-tory chow. Each treatment group consisted of 70 rats of each sex. A 30 % decrement in weight gain occurred at an NaF dose of 25 mg/kg per day. Evidence of fluoride toxicity was seen in the teeth, bones, and stomach, and the incidence and severity of these changes were related to the dose of NaF and the duration of exposure. Despite clear evidence of toxicity, NaF did not alter the incidence of preneoplastic and neoplastic lesions at any site in rats...
Fluorine is ubiquitously present in the environment. Living organisms are exposed to fluoride throug...
The aims of this study were to: (i) examine the toxic effects of sodium fluoride (NaF) in blood, liv...
Fluoride compounds are naturally present in soil, water and food. The objective of this study was to...
Fluoride has been widely used in dentistry because it is an effective caries prophylactic agent. How...
Fluoride is a naturally occurring contaminant in the water and it is essential for normal maintenanc...
Fluoride is naturally present in the earth's crust and can be found in rocks, coal, and clay; thus, ...
Fluoride has been widely used in dentistry as a caries prophylactic agent. However, there has been s...
Due to its properties, fluoride (NaF) is widely used in dentistry, as a tool for dental caries contr...
ABSTRACT:-Fluoride is a widespread non biodegradable and relatively persistent pollutant, which at l...
High fluoride content is known to cause dental and skeletal abnormalities. In addition, present revi...
Fluoride was the first compound utilized in the fluoridation of drinking water, and still used today...
A study on various regimens by which the same total amount of neutral sodium fluoride is applied to ...
The current study aimed to determine the pathological effects of chronic poisoning with sodium fluor...
By oral administration of various NaF solutions (drinking) to young rats and feeding them under the ...
AbstractThe present study was carried out to study the effect of acute doses of sodium fluoride on t...
Fluorine is ubiquitously present in the environment. Living organisms are exposed to fluoride throug...
The aims of this study were to: (i) examine the toxic effects of sodium fluoride (NaF) in blood, liv...
Fluoride compounds are naturally present in soil, water and food. The objective of this study was to...
Fluoride has been widely used in dentistry because it is an effective caries prophylactic agent. How...
Fluoride is a naturally occurring contaminant in the water and it is essential for normal maintenanc...
Fluoride is naturally present in the earth's crust and can be found in rocks, coal, and clay; thus, ...
Fluoride has been widely used in dentistry as a caries prophylactic agent. However, there has been s...
Due to its properties, fluoride (NaF) is widely used in dentistry, as a tool for dental caries contr...
ABSTRACT:-Fluoride is a widespread non biodegradable and relatively persistent pollutant, which at l...
High fluoride content is known to cause dental and skeletal abnormalities. In addition, present revi...
Fluoride was the first compound utilized in the fluoridation of drinking water, and still used today...
A study on various regimens by which the same total amount of neutral sodium fluoride is applied to ...
The current study aimed to determine the pathological effects of chronic poisoning with sodium fluor...
By oral administration of various NaF solutions (drinking) to young rats and feeding them under the ...
AbstractThe present study was carried out to study the effect of acute doses of sodium fluoride on t...
Fluorine is ubiquitously present in the environment. Living organisms are exposed to fluoride throug...
The aims of this study were to: (i) examine the toxic effects of sodium fluoride (NaF) in blood, liv...
Fluoride compounds are naturally present in soil, water and food. The objective of this study was to...