Original Article Evaluation of Serum Anti-Cardiolipin Antibody Titer of Patients with Chronic Periodontitis in Comparison with Periodontally Healthy Population

Objective: Evidence shows periodontally infected patients may be at a higher risk of thrombotic accidents and adverse pregnancy outcomes, via inducing systemic inflamma-tory mediators ’ production. Some authors have concluded that increasing systemic in-flammatory markers occurs together with increased serum levels of autoantibodies includ-ing anti-cardiolipin antibody (ACLA). Therefore, the aim of this study was to compare the serum ACLA level between patients with chronic periodontitis (CP) and those who are periodontally healthy. Materials and Methods: 51 Moderate and advanced CP patients (test group) and 49 pe-riodontally healthy people (Control group) were included in the study. Clinical parameters including PI, BOP, PPD, and CAL were measured. Serum ACLA level of all cases was measured by ELISA. The data were analyzed with t-test and Pearson's correlation. Results: There was a significant difference in serum ACLA level between test and control groups (P=0.001). Although all cases in both test and control groups showed a normal range of serum ACLA level. There was also a positive correlation between serum ACLA level and periodontal parame-ters including CAL, PPD, BOP and PI (P<0.001, <0.001, =0.001 and =0.002 respectively). In addition, a moderately positive correlation (P=0.003) between age and ACLA level was obtained. Conclusion: An increased serum ACLA level might be associated with chronic periodon-titis