Research Article Disparities in Liver Cancer Incidence by Nativity, Acculturation, and Socioeconomic Status in California Hispanics and Asians

Background:Asians and Hispanics have the highest incidence rates of liver cancer in the United States, but little is known about how incidence patterns in these largely immigrant populations vary by nativity, acculturation, and socioeconomic status (SES). Such variations can identify high-priority subgroups for prevention and monitoring. Methods: Incidence rates and rate ratios (IRR) by nativity among 5,400 Hispanics and 5,809 Asians diagnosed with liver cancer in 1988–2004 were calculated in the California Cancer Registry. Neighborhood ethnic enclave status and SES were classified using 2000 U.S. Census data for cases diagnosed in 1998–2002. Results: Foreign-born Hispanic males had significantly lower liver cancer incidence rates than U.S.-born Hispanic males in 1988–2004 (e.g., IRR 0.54, 95 % confidence interval [CI] 0.50–0.59 in 1997–2004), whereas foreign-bornHispanic females had significantly higher rates in 1988–1996 (IRR 1.42, 95%CI 1.18–1.71), but not 1997–2004. Foreign-bornAsianmales and females had up to 5-fold higher rates than the U.S.-born. Among Hispanic females, incidence rates were elevated by 21 % in higher-enclave versus lower-enclave neighbor-hoods, and by 24 % in lower- versus higher-SES neighborhoods. Among Asian males, incidence rates were elevated by 23 % in higher-enclave neighborhoods and by 21 % in lower-SES neighborhoods. In both racial/ ethnic populations,males and females in higher-enclave, lower-SESneighborhoodshadhigher incidence rates. Conclusions:Nativity, residential enclave status, and neighborhood SES characterizeHispanics andAsians with significantly unequal incidence rates of liver cancer, implicating behavioral or environmental risk factors and revealing opportunities for prevention. Impact: Liver cancer control efforts should especially target foreign-born Asians, U.S.-born Hispanic men, and residents of lower-SES ethnic enclaves. Cancer Epidemiol Biomarkers Prev; 19(12); 3106–18. 2010 AACR