Tubuloglomerular feedback and SNGFR autoregulation in the rat

simulation studies were undertaken to examine what influence the state of filtration dynamics has on single nephron glomer-ular filtration rate (SNGFR) autoregulation, to verify the pres-ence of partial autoregulation during tubuloglomerular feed-back (TGF) inhibition, and to determine whether small changes in tubular reabsorption could enhance the ability of TGF to regulate SNGFR during autoregulation. The experimental studies in hydropenic rats revealed partial autoregulation of glomerular capillary pressure (using the stop-flow method) and SNGFR during TGF inhibition and complete SNGFR autoreg-ulation with functional TGF. A small significant decrease in fractional volume reabsorption was observed in the distal mea-surements with increased arterial pressure. Results from a mathematical model of glomerular filtration suggest that SNGFR is inherently more sensitive to changes in arteria