Research Article Evaluating Genetic Risk for Prostate Cancer among Japanese and Latinos

Background: There have been few genome-wide association studies (GWAS) of prostate cancer among diverse populations. To search for novel prostate cancer risk variants, we conducted GWAS of prostate cancer in Japanese and Latinos. In addition, we tested prostate cancer risk variants and developed genetic riskmodels of prostate cancer for Japanese and Latinos. Methods: Our first-stage GWAS of prostate cancer included Japanese (cases/controls 1,033/1,042) and Latino (cases/controls 1,043/1,057) from theMultiethnic Cohort (MEC). Significant associations from stage I (P < 1.0 104) were examined in silico in GWAS of prostate cancer (stage II) in Japanese (cases/controls 1,583/3,386) and Europeans (cases/controls 1,854/1,894). Results: No novel stage I single-nucleotide polymorphism (SNP) outside of known risk regions reached genome-wide significance. For Japanese, in stage I, the most notable putative novel association was seen with 10 SNPs (P 8.0 106) at chromosome 2q33; however, thiswas not replicated in stage II. For Latinos, themost significant associationwasobservedwith rs17023900 at theknown3p12 risk locus (stage I:OR 1.45;P 7.01 105 and stage II: OR 1.58; P 3.05 107). The majority of the established risk variants for prostate cancer, 79 % and 88%, were positively associated with prostate cancer in Japanese and Latinos (stage I), respectively