Running Title: Magnetic Field Application Reduces Vascular Remodeling Corresponding Author:

2Magnetic field therapy has recently become a widely used complementary/alternative medicine for the treatment of vascular as well as other musculoskeletal pathologies including soft tissue injuries. Recent studies in our laboratory and others have suggested that acute static magnetic field (SMF) exposure can have a modulatory influence on the microvasculature, acting to normalize vascular function; however, the effect of chronic SMF exposure has not been investigated. This study aimed to measure, for the first time, the adaptive microvascular response to a chronic, 7-day continuous magnetic field exposure. Murine dorsal skinfold chambers were applied on day 0 and neodymium static magnets (or size and weight matched shams) were affixed to the chambers at day 0, where they remained until day 7. Separate analysis of arteriolar and venular diameters revealed that chronic SMF application significantly abrogated the luminal diameter expansion observed in sham treated networks. Magnet treated venular diameters were significantly reduced at day 4 and day 7 (34.3 % and 54.4%, respectively) as compared to sham treated vessels. Arteriolar diameters were also significantly reduced by magnet treatment at day 7 (50%) but no