SYNTHESIS OF NOVEL ANTIBACTERIAL AND ANTIFUNGAL -AMINO ACIDS AND HETEROCYCLIC COMPOUNDS

Utility of (E)-4-(acetylamino)phenyl-4-oxo-2-butenoic acid with new sulfur reagents e.g. 2-amino-5-aryl-thiadiazoles 2 to afford the corresponding adducts (3, 4, 5, 6). Reaction of the latter compounds with different electrophilic and nucleophilic reagents affords some important heterocycle such as various furanones, thiadiazoles, pyridazinones, imidazolo[2,3-b]1,3,4-thiadiazoles, thiadiazolopyrimidines, bezoxazinones, fused quinoxalinylquinazolinone