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Bra o P tma exercise reduces insulin secretion by altering the intracellular energy-sensitive AMP-activated kinase (AMPK) signaling protein content, CaMKII and AMPK phosphorylation levels were observed. These alterations were accompanied by an the insulin signaling, such as glucose transporter 4 (GLUT4), insulin secretion reduction in rodents (Zawalich et al. 1982, 257Journal of Endocrinology (2011) 208, 257–264involved in blood glucose homeostasis. In this sense, exercise increases liver insulin sensitivity (Hoene et al. 2009) reducing hepatic glucose production through the inhibition of FOXO/ HNF-4a pathway and TBR3 expression in insulin-resistant total hexokinase plus glucokinase activity in rat pancreatic islets, reducing intracellular glucose flux, in addition to ATP availability (Ueda et al. 2003), which, in turn, would increase AMP-to-ATP ratio, favoring AMPK activation. DOI: 10.1530/JOE-10-0450insulin receptor, and insulin receptor substrates 1/2, AMP-activated kinase (AMPK), protein kinase B/AKT substrat