Alteration by Acute Intracerebral

We reviewed the current literature and theories pertaining to the appearance of hemorrhage on MR images. New theories were formulated to explain the etiology of spin-echo (SE) and gradient-echo contrast on clinical MR images of hematomas at low and intermediate field strengths. It is our hope that these theories will prompt further experiments to prove or disprove their validity. The discussion of SE contrast focuses on the powerful MR effects mediated by changes in protein concentration. These changes are postulated to occur as a result of (1) clot matrix formation; (2) settling of RBCs, which increases the number of RBCs per unit volume and the total protein concentration; and (3) alterations in intracellular protein concentration caused by changes in RBC hydration. The contribution of acid methemoglobin to image contrast via the proton electron dipole-dipole mechanism is also included. The discussion of gradient-echo contrast focuses on the inhomogeneity that may be present within voxels that contain a blood clot. This inhomogeneity results when the voxel contains regions with different magnetic susceptibilities (i.e., clumped RBCs and serum). Two temporally arranged schemata for T2-weighted and T1-weighted SE scans ar