Add to ORKGFew studies have evaluated genetic susceptibility related to diabetes and obesity as a risk factor for neural tube defects (NTDs). The authors investigated 23 single nucleotide polymorphisms among 9 genes (ADRB3, ENPP1, FTO, LEP, PPARG, PPARGC1A, SLC2A2, TCF7L2, and UCP2) associated with type 2 diabetes or obesity. Samples were obtained from 737 NTD case-parent triads included in the National Birth Defects Preven-tion Study during 1999–2007. Log-linear models were used to evaluate maternal and offspring genetic effects. After application of the false discovery rate, there were 5 significant maternal genetic effects. The less common alleles at the 4 FTO single nucleotide polymorphisms showed a reduction of NTD risk (for rs1421085, relative r...
Impaired glucose metabolism during organogenesis is associated with an increased risk for major stru...
Background: Global incidence of obesity and Type 2 diabetes (T2D) has increased rapidly in the last ...
BACKGROUND: Neural tube defects are multifactorial malformations involving both environmental exposu...
Few studies have evaluated genetic susceptibility related to diabetes and obesity as a risk factor f...
Few studies have evaluated genetic susceptibility related to diabetes and obesity as a risk factor f...
Single-gene analyses indicate that maternal genes associated with metabolic conditions (e.g., obesit...
Single-gene analyses indicate that maternal genes associated with metabolic conditions (e.g., obesit...
Abstract Background Neural tube defects (NTDs) are common birth defects (~1 in 1000 pregnancies in t...
BackgroundNeural tube defects (NTDs), which are among the most common congenital malformations, are ...
AbstractBackgroundNeural tube defects (NTDs) are common birth defects (~1 in 1000 pregnancies in the...
The authors test single nucleotide polymorphisms (SNPs) in coding sequences of 12 candidate genes in...
Neural tube defects (NTDs) are the most common severely disabling birth defects in the United States...
Contains fulltext : 80133.pdf (publisher's version ) (Closed access)BACKGROUND: Ne...
SummaryFetuses with neural tube defects (NTDs) may be associated with syndromes, disorders, and mate...
Obesity is a complex multifactorial disorder with genetic and environmental factors. There is an inc...
Impaired glucose metabolism during organogenesis is associated with an increased risk for major stru...
Background: Global incidence of obesity and Type 2 diabetes (T2D) has increased rapidly in the last ...
BACKGROUND: Neural tube defects are multifactorial malformations involving both environmental exposu...
Few studies have evaluated genetic susceptibility related to diabetes and obesity as a risk factor f...
Few studies have evaluated genetic susceptibility related to diabetes and obesity as a risk factor f...
Single-gene analyses indicate that maternal genes associated with metabolic conditions (e.g., obesit...
Single-gene analyses indicate that maternal genes associated with metabolic conditions (e.g., obesit...
Abstract Background Neural tube defects (NTDs) are common birth defects (~1 in 1000 pregnancies in t...
BackgroundNeural tube defects (NTDs), which are among the most common congenital malformations, are ...
AbstractBackgroundNeural tube defects (NTDs) are common birth defects (~1 in 1000 pregnancies in the...
The authors test single nucleotide polymorphisms (SNPs) in coding sequences of 12 candidate genes in...
Neural tube defects (NTDs) are the most common severely disabling birth defects in the United States...
Contains fulltext : 80133.pdf (publisher's version ) (Closed access)BACKGROUND: Ne...
SummaryFetuses with neural tube defects (NTDs) may be associated with syndromes, disorders, and mate...
Obesity is a complex multifactorial disorder with genetic and environmental factors. There is an inc...
Impaired glucose metabolism during organogenesis is associated with an increased risk for major stru...
Background: Global incidence of obesity and Type 2 diabetes (T2D) has increased rapidly in the last ...
BACKGROUND: Neural tube defects are multifactorial malformations involving both environmental exposu...