In Vivo 3’P Nuclear Magnetic Resonance Spectroscopyof Bone Mineral for Evaluationof Osteoporosis

The mineral content of stationary bone samples can be quantified by 31Pnuclear magnetic resonance (NMR) spec-troscopy. The assay can be performed in regions of the anatomy that pose problems for absorptiometric techniques, because the mineral content is measured within a selected volumewithoutconcern for the geometry of the bone. In vivo 31P NMR spectra of the bones in human fingers and wrist are reported. Soft tissue such as marrow and skeletal muscle contributes little to the 31P NMR spectra of human fingers and wrist and thus should not seriously affect the accuracy of the mineral assay. 31P NMR spectrometry should prove helpful for confirming rapid bone mineral loss in those at risk and for monitoring response to treatment. AddItIonal Keyphrases: phosphorus calcium apatite bonemineral osteodystrophy noninvasiveanal