THE-JOURNAl. OF PHARMAcolOGY AND EXPERIMENTAl. THERAPEUTICS Copyright © 1981 b The American Society for Pharmacology and Experimental Therapeutics The Effect of Lesions in the Dorsal, Median and Magnus Raphe Nuclei on the Development of Tolerance to Etha

effect of lesions in the dorsal, median and magnus raphe nuclei on the development of tolerance to ethanol. J. Pharmacol. Exp. Ther. 218: 525-529, 1981. Electrolytic lesions were made in the median, the dorsal, the dorsal + median or magnus raphe nuclei of rats. Sham-control animals were also prepared through the same procedure with the exception that no current was delivered. After 1 week of recovery from surgery, a dose-response curve to the hypo-thermic and motor-impairment effects (moving belt test) was carried out to assess the initial response to ethanol. The maximal fall in temperature and maximum motor impairment were used to quantify the ethanol effects. Two days after the dose-response study, hypothermia and motor impairment were again determined in all animals after a test dose of ethanol. The animals in each main treatment grojp were then divide