References and Notes

our results uncover amitochondrial fusion-sensitive Ca2+/calcineurin pathway that regulates the cen-tral cardiac development factor Notch1, interrupt-ing cardiomyocyte proliferation and blocking fetal cardiac development. Cell fate in the developing fetus is determined by key nuclear transcription factors that drive specific differentiation gene programs. Mitochon-dria, the descendant of primordial bacteria living within unicellular organisms, participate in these processes by fueling them and by determining apoptotic and nonapoptotic cell death. Our find-ings invert this paradigm, demonstrating how a primary disturbance in organelle morphology can redirect the developmental fate of the host cell