Safety Evaluation of Zinc Threoninate

The acute toxicity of zinc threoninate chelate was assessed. The oral lethal dose 50 % (LD50) was 2710 mg/kg in female rats and 3160 mg/kg in male rats. Genotoxicity was assessed by Ames test in Salmonella typhimurium strains TA97, TA98, TA100, and TA102, by bone marrow mouse micronucleus test and a sperm abnormality test with mice. Thirty-day repeat dose toxicity study was conducted at oral daily doses of 0, 42, 169, and 675 mg/kg in rats. Teratogenicity was assessed at the same daily dose in preg-nant rats by gavage. No significant changes in body weight, food consumption, organ weight, relative organ weight, hematology, blood biochemistry, histopathology, behavior, mortality, sperm abnormality, mutagenicity, and micronucleus formation were observed and no clinical signs or adverse effects were detected. Zinc threoninate chelate had no significant teratogenic effect at a daily dose of 42 mg/kg. Keywords zinc threoninate chelate, safety, toxicity, genotoxicity, teratogenicity Zinc (Zn) is one of the important essential trace elements found in biological systems and also in many metalloproteins and metalloenzymes that exist in living organisms. As a component and cofactor of enzymes, it can regulate and control the struc