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(DLBCL) is the most frequent lymphoma subtype and accounts for approximately 30–40 % of all cases in adults.1 DLBCL represents a heterogeneous diagnostic category with respect to morphology, biology, and clinical outcome.1 The use of gene expression profiling significantly improved our understanding of this het-erogeneity, as 2 major molecular DLBCL subtypes that arise from different stages of B-cell differentiation were identified by this approach.2 Germinal center B-cell-like (GCB) DLBCLs are derived from germinal center B-cells and, accordingly, express genes such as BCL6 or LMO2 tha