Stroke A Journal of Cerebral Circubtion SEPTEMBER-OCTOBER 1981VOL. 12 NO. 5 Editorial What Method to Choose for Quantification of

QUANTIFICATION of pcrfusion is an important question in research in experimental cerebral ischemia, and numerous techniques of measurements based on various physical principles have been developed.1 The ideal method should permit con-tinuous total, regional, and local flow determinations. It should be applicable in unanesthetized intact animals without causing any structural or functional impairment. No presently available method can meet all of these requirements. Each technique has certain advantages and limitations that must be considered with respect to the problem under investigation. In the history of cerebrovascular research direct observation of the pial circulation was employed first.1 This method permits continuous monitoring of flui