ANTIBIOTIC PROPHYLAXIS IN PROSTATE BIOPSYClinical Urology ANTIBIOTIC PROPHYLAXIS IN PROSTATE BIOPSY. A COMPARATIVE RANDOMIZED CLINICAL ASSAY BETWEEN CIPROFLOXACIN, NORFLOXACIN AND CHLORAMPHENICOL

Objective: To compare, prospectively, 4 different schemes of antibiotic prophylaxis previ-ously to transrectal prostate biopsy. Materials and Methods: 257 patients were randomized in 4 groups: Group I: single dose of ciprofloxacin 2 hours before the procedure; Group II: ciprofloxacin 3 days; Group III: chlorampheni-col 3 days; and Group IV: norfloxacin 3 days. The complication rate was assessed in a blind way on the third and on the thirtieth days through a questionnaire. Groups were compared by the qui-square method and, in small samples, by the Fisher method, with statistical significance of 95%. Results: Complications index throughout the sample differed between the 4 groups of pa