Parkinson’s Disease

The basal ganglia (BG) have long been considered to play an important role in the control of movement and the pathophysiology of movement disorders, such as Parkinson’s disease (PD). Studies over the past decades have considerably broadened this view, indicating that the BG participate in multiple, parallel, largely segregated, cortico-subcortical reentrant pathways involving motor, associative and limbic functions. Research has shown that dysfunction within individual circuits is associated not only with movement disorders, but also with neuropsychiatric disorders. Accordingly, a number of movement dis-orders and neuropsychiatric disorders such as obsessive compulsive disorder and Tourette’s syndrome are viewed as “circuit disorders. ” We here discuss the changes in our current understanding of the anatomic and functional organization of BG circuits and related circuit disorders