Before During During Therapy Treatment o,p'-DDD with o,p'-DDD

The progesterone-receptor antagonist, RU 486 (mife-pristone), is also, at higher concentrations, an effective antagonist of glucocorticoid action in vitro and in vivo (1-3). In normal humans, RU 486 blocks glucocorticoid negative feedback at the hypothalamic-pituitary level, inducing a compensatory increase in plasma adrenocor-ticotropin (ACTH) and Cortisol levels (4, 5). In previous studies, patients with the Cushing syndrome caused b