Correlation of Angiographic Estimates of Myocardial Infarct Size and Accumulated Release

SUMMARY Accumulated creatine kinase MB isoenzyme release (2 CK-MB) during acute myocardial infarction was correlated with biplane left ventricular (LV) angiographic estimates of percent ab-normally contracting segment (%ACS) and ejection fraction (EF) in 35 patients who underwent diagnostic angiography at a mean of 33 ± 4 days post myocardial infarction (MI). Of the 35 patients, 18 had no evidence of prior MI and their 2 CK-MB showed good cor-relation with %ACS (r = 0.84) and with EF (r =- 0.78). An ad-ditional two patients with first (inferior) infarct secondary to stenosis of the right coronary artery proximal to the origin of the right ventricular arterial blood supply had disproportionately large 2 CK-MB, suggesting a combination of LV and RV necrosis. RECENT INTEREST in methods to reduce the extent of myocardial necrosis during acute myocardial infarction has underscored the importance of accurate techniques to asses