Central serous chorioretinopathy complicating systemic corticosteroid treatment

SUMMARY Central serous chorioretinopathy developed in 2 cases of retrobulbar neuritis during systemic treatment with corticosteroids. Fluorescein angiography confirmed leakage surrounded by central serous detachment of the retina. In one case the central serous chorioretinopathy recurred 3 times during 3 separate courses of treatment. Spontaneous recovery accompanied a reduction in steroid treatment to a low level. It is suggested that high dosage corticosteroids may damge the posterior blood-ocular barrier. Maculopathy complicating treatment with systemic corticosteroids (prednisolone,') or corticotrophic hormone (depot tetracosactrin2) has been reported. We have previously noted worsening of central serous chorioretinopathy (CSR) in 5 cases during systemic corticosteroid therapy. In this report we describe the development ofCSR during treatment of retrobulbar neuritis (RBN) in 2 cases, one of which developed 3 separate attacks of CSR during 3 separate courses o