Reasons for Regimen Change Among HIV/AIDS Patients Initiated on First Line Highly Active Antiretroviral

therapies are the drugs of HIV/AIDS treatment with no cure. Even though they inhibit viral replication, they may cause a number of adverse effects; which may end with treatment failure and/or regimen changes. Objective:- The study was aimed to determine the reasons for HAART regimen change among HIV/AIDS Patients on first line HAART during 12 months follow up in Fitche Hospital, ART Clinic. Methodology:- Hospital based retrospective study was conducted at Fitche Hospital, ART Clinic from January 28 to February 12, 2013 by reviewing patients ’ information sheets and physician diagnostic cards. The data was categorized and analyzed manually using calculator for statistical analysis. The results has been interpreted and presented by tables and graphs. Results:- Majority of the patients 29(42.65%) were on D4T/3TC/NVP at the beginning of the Highly Active Antiretroviral Treatment. The main reason for regimen change was toxicity 56(72.73%) followed by, treatment failure 11 (14.23%), new drug available 7(9.09%), co morbidity 2(2.60%), and 1(1.30%) patient refused to took the drug. From all the toxicities reported, lipoatrophy, which accounted for 73.47 % of the toxicities, was the most common. Conclusion:- Results shows that majority of patients were initiated D4T/3TC/NVP compared to other regimens. Toxicity appears as the main reason for treatment and regimen change in this study. The other reasons include; treatment failure, new drug available, co morbidity and patient refused to took the drug respectively