The present study describes atypical Leydig cell (LC) hyperplasia in 20-week-old Sprague-Dawley rats with low testosterone and high luteinizing hormone levels after prenatal administration of 100 mg/kg/day di(n-butyl) phthalate on days 12 to 21 postconception. Light microscopy revealed LC hyperplasia surrounded by severely degenerated seminiferous tubules. Aggregated LCs had large ovoid nuclei with nucleoli and abundant eosino-philic cytoplasm. Immunohistochemical analysis showed expression of proliferating cell nuclear antigen and vimentin in many hyperplastic LCs. Electron microscopy revealed atypical nuclei, abundant free ribosomes, stripped rough endoplasmic reticulum, intermediate-size filaments, elon-gated cytoplasmic filopodia, atypi...
This study sought to establish whether reduced androgen levels/action in the fetal rat testis induce...
Pregnancy exposure to di(n-butyl) phthalate (DBP) in rats induces a testicular dysgenesislike syndro...
A testicular dysgenesis-like syndrome is induced in rats by fetal exposure todi(n-butyl) phthalate (...
Abstract: We recently reported that prenatal rat exposure to di(n-butyl) phthalate (DBP) induced Ley...
The definitive version is available at www.blackwell-synergy.comFoetal exposure of male rats to di(n...
Exposures to di-(2-ethylhexyl) phthalate (DEHP) have been shown to be associated with decreased adul...
When 100 mg/kg/day of di(n-butyl) phthalate (DBP) was intragastrically administered to pregnant Spra...
When 100 mg/kg/day of di(n-butyl) phthalate (DBP) was intragastrically administered to pregnant Spra...
Diethylhexylphthalate (DEHP) has been classified as an antiandrogen. However, whether in utero and l...
Phthalates, the most abundantly produced plasticizers, leach out from polyvinyl chloride plastics an...
<p>(A–B) Double immunofluorescence for 3β-HSD (blue) and Sox-9 (red) on e21.5 testis sections from (...
Maternal exposure to estrogenic xenobiotics or phthalates has been implicated in the distortion of e...
<p>(A–B) Triple immunofluorescence for SMA (blue), 3β-HSD (red) and COUP-TFII (green) on fetal testi...
Dicyclohexyl phthalate (DCHP) is one of the phthalate plasticizers. The objective of the present stu...
<p>(A–B) Triple immunofluorescence for SMA (blue), 3β-HSD (red) and COUP-TFII (green) on testis sect...
This study sought to establish whether reduced androgen levels/action in the fetal rat testis induce...
Pregnancy exposure to di(n-butyl) phthalate (DBP) in rats induces a testicular dysgenesislike syndro...
A testicular dysgenesis-like syndrome is induced in rats by fetal exposure todi(n-butyl) phthalate (...
Abstract: We recently reported that prenatal rat exposure to di(n-butyl) phthalate (DBP) induced Ley...
The definitive version is available at www.blackwell-synergy.comFoetal exposure of male rats to di(n...
Exposures to di-(2-ethylhexyl) phthalate (DEHP) have been shown to be associated with decreased adul...
When 100 mg/kg/day of di(n-butyl) phthalate (DBP) was intragastrically administered to pregnant Spra...
When 100 mg/kg/day of di(n-butyl) phthalate (DBP) was intragastrically administered to pregnant Spra...
Diethylhexylphthalate (DEHP) has been classified as an antiandrogen. However, whether in utero and l...
Phthalates, the most abundantly produced plasticizers, leach out from polyvinyl chloride plastics an...
<p>(A–B) Double immunofluorescence for 3β-HSD (blue) and Sox-9 (red) on e21.5 testis sections from (...
Maternal exposure to estrogenic xenobiotics or phthalates has been implicated in the distortion of e...
<p>(A–B) Triple immunofluorescence for SMA (blue), 3β-HSD (red) and COUP-TFII (green) on fetal testi...
Dicyclohexyl phthalate (DCHP) is one of the phthalate plasticizers. The objective of the present stu...
<p>(A–B) Triple immunofluorescence for SMA (blue), 3β-HSD (red) and COUP-TFII (green) on testis sect...
This study sought to establish whether reduced androgen levels/action in the fetal rat testis induce...
Pregnancy exposure to di(n-butyl) phthalate (DBP) in rats induces a testicular dysgenesislike syndro...
A testicular dysgenesis-like syndrome is induced in rats by fetal exposure todi(n-butyl) phthalate (...
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