LETTER TO THE EDITOR Reply: Intermediate and normal

sized CGG repeat on the FMR1 gene does not negatively affect donor ovarian response Sir, The general population distribution of CGG repeats on the FMR1 gene (Fragile X syndrome) shows a prominent peak between 29 and 30 triple repeats (Fu et al., 1991). From this data, 30 repeats have been suggested as the switching point between positive and negative effects of the FMR1 gene product (Chen et al., 2003). There-fore, special attention could be taken into normal and intermediate range. For intermediate carriers, the main drawback to show an asso-ciation between premature ovarian failure (POF) and CGG repeats is the cut-off for this range. A recent study considers intermediate sized 35–58 and concludes that intermediate sizes should not be consid-ered a high-risk factor for POF (Bennett et al., 2010). It is more difficul