OBJECTIVE—Adiponectin receptor-1 (AdipoR1) expression in skeletal muscle has been suggested to play an important role in insulin resistance and diabetes. We aimed at evaluating the presence of novel AdiopR1 splice variants in human muscle and their regulation under physiological and pathophysiological states. RESEARCH DESIGN AND METHODS—AdipoR1 59UTR mRNA transcripts, predicted from bioinformatics data, were eval-uated in fetal and adult human tissues. Expression and function of the identified transcripts were assessed in cultured human skeletal muscle cells and in muscle biopsies obtained from indi-viduals with normal glucose tolerance (NGT) and type 2 diabetes (n = 49). RESULTS—Screening of potential AdipoR1 59UTR splice variants revealed...
AbstractWhite adipose tissue (WAT) is a key energy depot in humans and most animals. Traditionally, ...
BACKGROUND: Insulin resistance (IR) in skeletal muscle is a key feature of the pre-diabetic state, h...
SummaryInsulin resistance is associated with impaired skeletal muscle oxidation capacity and reduced...
OBJECTIVE—Adiponectin receptor-1 (AdipoR1) expression in skeletal muscle has been suggested to play ...
OBJECTIVE — Adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2, respectively) mediate the effects of...
The insulin-sensitizing effect of adiponectin (1–4) is mediated via adiponectin receptors (AdipoR1 a...
Objective: This study aimed to investigate the regulation of adiponectin receptors 1 (AdipoR1) and 2...
Objective: This study aimed to investigate the regulation of adiponectin receptors 1 (AdipoR1) and 2...
Pancreatic beta cell dysfunction is an early and crucial pathogenic factor in the development of typ...
AIMS/HYPOTHESIS: Adiponectin is important in the regulation of insulin sensitivity in man. Its recep...
The purpose of this study was to investigate the expression level of adiponectin and its related mol...
Hypoadiponectinemia and adiponectin resistance are implicated in the aetiology of obesity-related ca...
<div><p>The purpose of this study was to investigate the expression level of adiponectin and its rel...
Adiponectin has been shown to regulate glucose and fatty acid uptake and metabolism in skeletal musc...
Peroxisome proliferator-activated receptor-? (PPAR?) is a key regulator of fatty acid oxidation in s...
AbstractWhite adipose tissue (WAT) is a key energy depot in humans and most animals. Traditionally, ...
BACKGROUND: Insulin resistance (IR) in skeletal muscle is a key feature of the pre-diabetic state, h...
SummaryInsulin resistance is associated with impaired skeletal muscle oxidation capacity and reduced...
OBJECTIVE—Adiponectin receptor-1 (AdipoR1) expression in skeletal muscle has been suggested to play ...
OBJECTIVE — Adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2, respectively) mediate the effects of...
The insulin-sensitizing effect of adiponectin (1–4) is mediated via adiponectin receptors (AdipoR1 a...
Objective: This study aimed to investigate the regulation of adiponectin receptors 1 (AdipoR1) and 2...
Objective: This study aimed to investigate the regulation of adiponectin receptors 1 (AdipoR1) and 2...
Pancreatic beta cell dysfunction is an early and crucial pathogenic factor in the development of typ...
AIMS/HYPOTHESIS: Adiponectin is important in the regulation of insulin sensitivity in man. Its recep...
The purpose of this study was to investigate the expression level of adiponectin and its related mol...
Hypoadiponectinemia and adiponectin resistance are implicated in the aetiology of obesity-related ca...
<div><p>The purpose of this study was to investigate the expression level of adiponectin and its rel...
Adiponectin has been shown to regulate glucose and fatty acid uptake and metabolism in skeletal musc...
Peroxisome proliferator-activated receptor-? (PPAR?) is a key regulator of fatty acid oxidation in s...
AbstractWhite adipose tissue (WAT) is a key energy depot in humans and most animals. Traditionally, ...
BACKGROUND: Insulin resistance (IR) in skeletal muscle is a key feature of the pre-diabetic state, h...
SummaryInsulin resistance is associated with impaired skeletal muscle oxidation capacity and reduced...