Nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric adenocarcinomas

Background: Nonsteroidal anti-inflammatory drug (NSAID) use has been associated with a reduced risk of colon cancer; further epidemiologic data appear consistent for stomach and esophageal adenocarcino-mas. Yet, data on potential confounding effects by upper gastrointestinal tract (UGI) disorders on adeno-carcinomas of the UGI are limited. Methods: This study recruited newly diagnosed patients with esophageal adenocarcinoma (n = 220), gastric cardia adenocarcinoma (n = 277), or distal gastric adenocarcinoma (n = 441) as well as 1,356 control subjects in Los Angeles County. Unconditional multi-variable logistic regression analyses were done to evaluate the association between regular NSAID use