Indian Journal of Medical Microbiology, (2006) 24 (1):7-19 Review Article MENINGOCOCCAL DISEASE: HISTORY, EPIDEMIOLOGY, PATHOGENESIS, CLINICAL MANIFESTATIONS, DIAGNOSIS, ANTIMICROBIAL SUSCEPTIBILITY AND PREVENTION

Meningoccocal disease has repeatedly caused outbreaks worldwide. There has been sudden surge of cases of meningococcemia and meningococcal meningitis in early 2005 in Delhi, India and neighboring states of Uttar Pradesh and Haryana. As of June 17, 2005, 429 probable cases of meningococcal disease have been reported in Delhi out of which 128 cases have revealed microbiological evidence of Neisseria meningitidis. It is possible that the number of cases was in excess of the numbers notified. During this episode drug susceptibility testing by MIC method (E-test) using break points recently recommended by NCCLS/CLSI, revealed that all isolates were sensitive to penicillin, ampicillin, rifampicin and ceftriaxone. As regards to ciprofloxacin, about two third of the isolates tested were found to be ‘non-susceptible ’ (MIC =0.03µg/mL- 0.190µg/mL). All the isolates were found resistant to cotrimoxazole (MIC> 16µg/mL). Repeated outbreaks, decreased susceptibility to ciprofloxacin, which is commonly used for chemoprophylaxis of meningococcal disease, highlights the need for a constant surveillance system. Present review deals with various aspects of Neisseria meningitidis and meningococcal disease in view of recent episode. Key words: Neisseria meningitidis, polysaccharide vaccines, ciprofloxacin resistance, outbreak, Delhi, India History sulfonamides and other antimicrobial agents led to a further decline in case fatality rates. Despite treatment wit