Add to ORKGIn addition to their well known control of reproduc-tive functions, estrogens modulate important physiological processes. The identification of com-pounds with tissue-selective activity will lead to new drugs mimicking the beneficial effects of es-trogen on the prevention of osteoporosis and car-diovascular or neurodegenerative diseases, while avoiding its detrimental proliferative effects. As an innovative model for the in vivo identification of new selective estrogen receptor modulators (SERMs), we engineered a mouse genome to ex-press a luciferase reporter gene ubiquitously. The constructs for transgenesis consist of the reporter gene driven by a dimerized estrogen-responsive element (ERE) and a minimal promoter. Insulato
Estrogen Receptors (ERs) are members of the Nuclear Receptor (NR) super family that mediate a divers...
Using gene-targeting techniques, transgenic, knock-out (KG) mice, homozygousfor the disrupted estrog...
In females, estrogens play a key role in reproduction and have beneficial effects on the skeletal, c...
In addition to their well known control of reproductive functions, estrogens modulate important phys...
In recent years several studies demonstrated the presence of estrogen receptors in mammalian tissues...
Through intracellular receptors, estrogens control growth, differentiation and function of not only ...
The limited success, in terms of prevention of diseases associated to menopause, of hormone replacem...
In the latest few years, the merging of imaging and animal engineering technologies has led to the g...
International audienceThe ancestral status of estrogen receptor (ER) in the family of the steroid re...
Introduction: "Tissue-selective estrogen complex" or TSEC is a novel concept of estrogen replacement...
The ability of 14 structurally diverse estrogenic compounds to induce reporter gene expression media...
Molecular imaging, i.e. the non-invasive imaging of target macromolecules and biological processes i...
Using a mouse model engineered to measure estrogen receptor (ER) transcriptional activity in living ...
International audienceGiven this widespread role for estrogen in human physiology, it is not surpris...
SCREENING ASSAY FOR SELECTIVE ESTROGEN RECEPTOR MODULATORSElena Sirbu, BSUniversity of Pittsburgh, 2...
Estrogen Receptors (ERs) are members of the Nuclear Receptor (NR) super family that mediate a divers...
Using gene-targeting techniques, transgenic, knock-out (KG) mice, homozygousfor the disrupted estrog...
In females, estrogens play a key role in reproduction and have beneficial effects on the skeletal, c...
In addition to their well known control of reproductive functions, estrogens modulate important phys...
In recent years several studies demonstrated the presence of estrogen receptors in mammalian tissues...
Through intracellular receptors, estrogens control growth, differentiation and function of not only ...
The limited success, in terms of prevention of diseases associated to menopause, of hormone replacem...
In the latest few years, the merging of imaging and animal engineering technologies has led to the g...
International audienceThe ancestral status of estrogen receptor (ER) in the family of the steroid re...
Introduction: "Tissue-selective estrogen complex" or TSEC is a novel concept of estrogen replacement...
The ability of 14 structurally diverse estrogenic compounds to induce reporter gene expression media...
Molecular imaging, i.e. the non-invasive imaging of target macromolecules and biological processes i...
Using a mouse model engineered to measure estrogen receptor (ER) transcriptional activity in living ...
International audienceGiven this widespread role for estrogen in human physiology, it is not surpris...
SCREENING ASSAY FOR SELECTIVE ESTROGEN RECEPTOR MODULATORSElena Sirbu, BSUniversity of Pittsburgh, 2...
Estrogen Receptors (ERs) are members of the Nuclear Receptor (NR) super family that mediate a divers...
Using gene-targeting techniques, transgenic, knock-out (KG) mice, homozygousfor the disrupted estrog...
In females, estrogens play a key role in reproduction and have beneficial effects on the skeletal, c...