targets in AML and responds to EZH2 inhibition

Boolean implications are a useful computational algorithm to mine mutation-specific methylation relationships in large cancer data sets. Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML, and inhibition of EZH2 induces myeloid differentiation. Acutemyeloid leukemia (AML) is associatedwith deregulation of DNAmethylation; how-ever, many cases do not bear mutations in known regulators of cytosine guanine dinu-cleotide (CpG) methylation. We found that mutations inWT1, IDH2, and CEBPA were strongly linked to DNA hypermethylation in AML using a novel integrative analysis o