Cytogenetic Studies in Acute Myelocytic Leukemia with Special Emphasis on the Occurrence of Ph ’ Chromosome

Cytogenetic studies were carried out on 103 unselected patients with acute mye-logenous leukemia (AML) at the Clinical Center of the National Institutes of Health. Seventy-three patients (70.9%) had a normal karyotype and 30 patients (29.1%) were aneuploid. No unique chromosomal abnormalities were found in patients with aneuploidy; however, there was a significantly higher incidence of G group involvement. Four cases had a history of radiation exposure; three of these four patients had a normal kary-otype and one had one Ph1 chromosome in her bone marrow cells. Another pa