Association of Complement C3 Gene Variants With Renal Transplant Outcome of Deceased Cardiac Dead Donor Kidneys

Local renal complement activation by the donor kid-ney plays an important role in the pathogenesis of renal injury inherent to kidney transplantation. Con-tradictory results were reported about the protective effects of the donor C3F allotype on renal allograft out-come. We investigated the influence of the donor C3F allotype on renal transplant outcome, taking all dif-ferent donor types into account. C3 allotypes of 1265 donor–recipient pairs were determined and divided into four genotypic groups according to the C3F allo-type of the donor and the recipient. The four genotypic groups were analyzed for association with primary nonfunction (PNF), delayed graft function, acute re-jection, death-censored graft survival and patient sur-vival. Considering all donor types, multivariable analy