Protective effects of vitamin E on central nervous system in streptozotocin-induced diabetic rats

Objective: To evaluate the histopathological and antioxi-dant effects of vitamin E (VE) treatment on brain tissue in streptozotocin (STZ)-induced diabetic rats. Methods: Thirty two male Wistar albino rats were used. The study comprised four groups of 8 rats: Group A- un-treated group, group B- diabetic group, group C- VE and group D- diabetic plus VE. In the diabetic groups, diabetes was induced by a single intraperitoneal injection of 65 mg/ kg STZ. Vitamin E was given 50 mg/kg/day i.p. for three weeks. Concentrations of glucose, malondialdehyd