PHEOCHROMOCYTOMA OF THE ADRENAL GLAND WITH GRANULOSA CELL TUMOR AND NEUROFIBROMATOSIS: REPORT OF A CASE WITH FATAL OUTCOME FOL- LOWING ABDOMINAL AORTOGRAPHY *

PHEOCHROMOCYTOMA today cannot be considered an unusually rare tumor, since numerous isolated cases as well as small series have been reported. In 1952 Aaronx stated that about 300 cases had been published, but that they prob-ably represent but a small fraction of the actual number. The association of pheochromocytoma with a malignant neoplasia, however, is much more infrequent. Four cases have been reported associated with neuro-blastomas.2 ' 3 » 4»5 One case had a "neurogenic sarcoma, " 6 one a carcinoma of the rectum,7 and another a neurofibromatosis with "malignant degeneration. " 8 The second case of Mandeville and Sahyoun9 and the recent one of Tamura and Lawrence10 will not be considered here, since they are both cases of malignant pheochromocytomas, the former associated with bronchogenic carcinoma and the latter with a malignant schwannoma of the thorax. The total cases of pheochromocytoma associated with malignant neoplasia at the present time stand at seven, to the best of our knowledge. In 1953 Glushien and collaborators u reviewed the literature on pheochromo