PROSTATIC INTRAEPITHELIAL NEOPLASIA AND ITS ASSOCIATION WITH BENIGN PROSTATIC HYPERPLASIA AND CARCINOMA PROSTATE

Identification of premalignant lesion which help in early diagnosis of carcinoma prostate is a newer development in histopathology of prostate. Prostatic intraepithelial neoplasia is only one of these lesions and is best known. The aim of present study is to identify foci of PIN in ductoacinar lining epithelium of prostate and its association with benign prostatic hyperplasia (BPH) and carcinoma of prostate. Micro sections from 110 prostate specimens received in a tertiary care center were studied extensively and analysed. Our study revealed, out of 96 cases of BPH 29 (30%) showed PIN and out of 10 cases of BPH with adenocarcinoma 7 (70%) showed PIN whereas high grade PIN was observed in 3 cases (75%) of total 4 cases of carcinoma. PIN especially high grade type was the most commonly observed lesion in cases of adenocarcinoma, thereby suggesting it to be the most likely precursor of carcinoma prostat