American Journal of Advanced Drug Delivery www.ajadd.co.uk American Journal of Advanced Drug Delivery www.ajadd.co.uk Original Article Formulation and Evaluation of Valsartan Oral Dispersible Tablets by Direct Compression Method

The objective of the present study is to develop a pharmaceutically stable, cost effective and quality improved robust formulation of Valsartan Immediate Release tablets. The aim of work is related to the formulation and evaluation of 10mg of dispersible tablet. Valsartan belongs to a class of antihypertensive agents called angiotensin II receptor blockers (ARBs). Total nine formulations were prepared by direct compression method in which the concentration of the superdisintegrants is varied to evaluate the effect on the disintegration time of valsartan mouth dissolving tablets. The superdisintegrants, involved in preparation are Sodium starch glycolate, Avicel PH 102, Low HPC. The prepared batches of tablets were evaluated for micromeritic parameters, weight variation, hardness, friability, wetting time, In vitro dispersion time, drug content and In vitro dissolution studies. In Formulations F1, F2, F3