Topics
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Major Histocompatibility ComplexBiomolecule
asthmaDisease
T lymphocytesAnatomical structure
T cellAnatomical structure
antigenChemical compound
thiolChemical compound
allergenProtein
CD4Biomolecule
Gamma-interferon-inducible lysosomal thiol reductase (GILT) is known to reduce disulfide bonds present in proteins internalized by antigen presenting cells, facilitating optimal processing and presentation of peptides on Major Histocompatibility Complex class II molecules, as well as the subsequent activation of CD4-positive T lymphocytes. Here, we show that GILT is required for class II-restricted processing and presentation of immunodominant epitopes from the major house dust mite allergen Der p 1. In the absence of GILT, CD4-positive T cell responses to Der p 1 are significantly reduced, resulting in mitigated allergic airway inflammation in response to Der p 1 and house dust mite extracts in a murine model of asthma
Asthma, a chronic inflammatory disease of the lung, is characterized by reversible airway obstructio...
Rationale: One of the immunopathological features of allergic inflammation is the infiltration of he...
Rationale: Although epidemiological studies have linked asthma susceptibility and severity to polymo...
Gamma-interferon-inducible lysosomal thiol reductase (GILT) is known to reduce disulfide bonds prese...
Asthma is a chronic life-threatening disease of worldwide importance. Although allergic asthma and r...
A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment...
Serodominant group 1 allergens of house dust mites (HDMs) are cysteine protease digestive enzymes. B...
Background House dust mite (HDM) allergens have been reported to increase airway epithelial permeabi...
Aeroallergens such as house dust mite (HDM), cockroach, and grass or tree pollen are innocuous subst...
Aeroallergens such as house dust mite (HDM), cockroach, and grass or tree pollen are innocuous subst...
Protein S-glutathionylation (PSSG) is an oxidant-induced post-translational modification of protein ...
The polarization of the immune response toward a Th2 or a Th1 profile can be mediated by dendritic c...
Rationale: Although epidemiological studies have linked asthma susceptibility and severity to polymo...
Rationale: Although epidemiological studies have linked asthma susceptibility and severity to polymo...
Dendritic cells are a major source of extracellular thiols needed for T cell activation, a process i...
Asthma, a chronic inflammatory disease of the lung, is characterized by reversible airway obstructio...
Rationale: One of the immunopathological features of allergic inflammation is the infiltration of he...
Rationale: Although epidemiological studies have linked asthma susceptibility and severity to polymo...
Gamma-interferon-inducible lysosomal thiol reductase (GILT) is known to reduce disulfide bonds prese...
Asthma is a chronic life-threatening disease of worldwide importance. Although allergic asthma and r...
A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment...
Serodominant group 1 allergens of house dust mites (HDMs) are cysteine protease digestive enzymes. B...
Background House dust mite (HDM) allergens have been reported to increase airway epithelial permeabi...
Aeroallergens such as house dust mite (HDM), cockroach, and grass or tree pollen are innocuous subst...
Aeroallergens such as house dust mite (HDM), cockroach, and grass or tree pollen are innocuous subst...
Protein S-glutathionylation (PSSG) is an oxidant-induced post-translational modification of protein ...
The polarization of the immune response toward a Th2 or a Th1 profile can be mediated by dendritic c...
Rationale: Although epidemiological studies have linked asthma susceptibility and severity to polymo...
Rationale: Although epidemiological studies have linked asthma susceptibility and severity to polymo...
Dendritic cells are a major source of extracellular thiols needed for T cell activation, a process i...
Asthma, a chronic inflammatory disease of the lung, is characterized by reversible airway obstructio...
Rationale: One of the immunopathological features of allergic inflammation is the infiltration of he...
Rationale: Although epidemiological studies have linked asthma susceptibility and severity to polymo...
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