Comparison of Clinical and Laboratory Characteristics Between Adult-Onset Type 1 Diabetes and Latent Autoimmune Diabetes in Adults

A lthough they do not initially requireinsulin, diabetic adults presentingautoantibodies against-cells (anti-GAD antibody [GADA] and anti–islet cell antibody [ICA]) more rapidly develop the need for insulinization, a fact characteriz-ing latent autoimmune diabetes in adults (LADA) (1,2). Differences between LADA and type 2 diabetes (3–6) and between children and adults with type 1 diabetes (7) have been reported. In contrast, few studies are available comparing type 1 di-abetes diagnosed during adulthood with LADA, with the results not being consis-tent (4,5,8). Therefore, the aim of the present study was to investigate clinical and laboratory parameters in patient